* Liverpool's 8–0 victory over Beşiktaş at Anfield on 6 November 2007 became the highest scoring win (excluding qualifying or preliminary rounds) in the Champions League era.
* Filippo Inzaghi surpassed Gerd Müller as the all-time highest scorer in European competitions when he scored his 63rd European club competition goal, in Milan's 1–0 victory over Celtic on 4 December 2007. He is also currently the highest-scoring Italian player in the history of European competition, having scored 34 of his 63 European competition goals for Milan.
* Lazio goalkeeper Marco Ballotta became the oldest player to ever play in the Champions League when he was fielded in the match against Real Madrid on 11 December 2007. Aged 43, he was three years older than the previous record owner, Alessandro Costacurta, who was 40 when he played for Milan against AEK Athens in November 2006.
* Dynamo Kyiv failed to gain a single point in Group F, becoming the seventh side to finish the first group stages with zero points earned since the format change of the European Cup in 1992. The other teams to finish with zero points were: Košice (1997-98), Fenerbahçe (2001-02), Spartak Moscow (2002-03), Anderlecht (2004-05), Rapid Wien (2005-06), and Levski Sofia (2006-07).
* Fenerbahçe reached the quarter-finals of the European Cup for the first time in their history. They are the second Turkish side to qualify for the quarter-finals in the Champions League era, the other being Galatasaray in 2000-01.
* Schalke 04 qualified for the quarter-finals of the European Cup for the first time since 1958-59.
* For the fourth consecutive year, the defending champions were eliminated in the first knockout round. Since the implementation of the 16-team knockout stage in the 2003-04 season, Milan, in 2003-04, were the only defending champion to make it out of the first knockout round, as they lost in the quarter-finals that year.
* Sevilla's penalty defeat to Fenerbahçe in the first knockout round marked the first time they had been knocked out of a European tournament since 2004-05.
* Milan's 0–2 loss to Arsenal in the second leg of the first knockout round was the club's first ever defeat to English opposition at the San Siro.
* The elimination of Milan by Arsenal means that no club has successfully defended their title in the Champions League era as yet.
* Manchester United's victory over Roma in the second leg of the quarter-finals was their eleventh successive home win, surpassing Juventus' record of ten that was set between the 1995-96 and 1997-98 seasons – they subsequently extended the run of home victories to twelve with a 1–0 defeat of Barcelona in the semi-finals.
* Bojan Krkić was the first ever scorer in the Champions League to have been born in the 1990s, when he scored the only goal in Barcelona's 1–0 quarter-final first leg win against Schalke 04. He is also the second youngest scorer in the Champions League behind Ghanaian forward Peter Ofori-Quaye, then-playing for Olympiacos.[4]
* 2007–08 marks the first season in the competition's history that four teams from the same country have reached the quarter-final stage, following the progression of Arsenal, Chelsea, Liverpool and Manchester United into the final stages.
* Liverpool and Arsenal played each other three times in a week in April 2008; they first played each other in the Champions League quarter-final first leg on 2 April, before a league game on 5 April, both at the Emirates Stadium. The teams then moved up to Liverpool to play the Champions League quarter-final second leg.
* Liverpool and Chelsea played each other in the semi-finals of the Champions League for the third time in four years (the other two matchups occured during the 2004-05 and 2006-07 seasons). It is also the fourth time in four years that the two teams have been drawn together in the Champions League, including the group stage in 2005-06.
* The same three English sides (Chelsea, Liverpool and Manchester United) played in the semi-finals for the second season in a row. The only team that was not in the previous season's semi-finals was Barcelona. This semi-final line-up meant that there would be an English team in the final for the fourth season in a row.
* The final between Chelsea and Manchester United is the first all-English final in the history of the European Cup and the third final between two teams from the same country. The others were in 2000 and 2003.
* Chelsea reached the Champions League final for the first time in their history.
* Coincidentally, while two English teams (Manchester United and Chelsea) will be contesting the Champions League final in Moscow, Russia, a Russian team (Zenit St. Petersburg) will be contesting the UEFA Cup final in Manchester, England. Also, Chelsea FC is owned by a Russian.
* For the first time in Champions League history, none of the English teams were eliminated by a non-English team. Arsenal were eliminated by Liverpool, who were eliminated by Chelsea, who will now face Manchester United in the final.